Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 0.806


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
TAL1 6886 T-cell acute lymphocytic leukemia 1
TCF12 6938 transcription factor 12
TCF3 6929 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF3chr19_-_16012460.572.2e-02Click!
TCF4chr18_-_51406841-0.505.1e-02Click!
TCF12chr15_+_55298908-0.282.9e-01Click!
TAL1chr1_-_47468029-0.204.7e-01Click!


Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_158008763 1.956 NM_004288
CYTIP
cytohesin 1 interacting protein
chr1_+_32489426 1.429 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr9_-_129707392 1.373 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr1_-_158948176 1.288 NM_001778
CD48
CD48 molecule
chr19_-_44060729 1.033 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chrX_-_154216929 0.981 NM_001289
CLIC2
chloride intracellular channel 2
chr19_+_17499064 0.742 FAM129C
family with sequence similarity 129, member C
chr16_+_11966464 0.729 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr10_+_85923473 0.617 NM_207373
C10orf99
chromosome 10 open reading frame 99
chr19_+_4442610 0.609 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr6_-_41811916 0.605 NM_001167827
TFEB
transcription factor EB
chr20_-_39199936 0.553


chr5_-_142764295 0.542 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr10_+_11246934 0.541 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr14_-_93493519 0.537 NM_016150
ASB2
ankyrin repeat and SOCS box containing 2
chr2_-_225519974 0.508 DOCK10
dedicator of cytokinesis 10
chr12_+_115481568 0.502 NM_001085481
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr18_+_19826734 0.499 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chrX_+_55951280 0.486


chr2_-_65013070 0.475 LOC400958
hypothetical LOC400958
chr1_-_92724181 0.471 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr4_-_185921384 0.465 ACSL1
acyl-CoA synthetase long-chain family member 1
chr12_-_101835183 0.462 PAH
phenylalanine hydroxylase
chr6_-_11490487 0.458 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_+_65164167 0.445 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr1_-_176205672 0.425 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr12_+_118590039 0.400 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chrX_+_128741562 0.400 NM_018990
SASH3
SAM and SH3 domain containing 3
chr17_-_53761119 0.397 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr17_-_46479127 0.388 SPAG9
sperm associated antigen 9
chr12_-_101835026 0.383 PAH
phenylalanine hydroxylase
chr22_+_43451600 0.377 PRR5
proline rich 5 (renal)
chr11_+_46651090 0.375 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr8_-_81155564 0.369 NM_001025252
TPD52
tumor protein D52
chr2_-_151854619 0.365 NM_004688
NMI
N-myc (and STAT) interactor
chr6_-_66473790 0.359 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr6_+_167456230 0.357 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr5_-_131907071 0.355 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr1_+_50342168 0.355 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_+_56286212 0.352 NM_032269
CCDC135
coiled-coil domain containing 135
chr1_+_242283129 0.345 NM_006352
ZNF238
zinc finger protein 238
chr12_-_101835510 0.341 NM_000277
PAH
phenylalanine hydroxylase
chrX_-_46503415 0.336 NM_032591
SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr5_-_142764168 0.334 NM_001018076
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr17_-_9863929 0.332 GAS7
growth arrest-specific 7
chr17_-_44641741 0.328 NM_031498
NM_001198755
NM_001198756
GNGT2


guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2


chr19_+_18069596 0.322 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr3_-_10307408 0.321 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr16_-_29817841 0.313 NM_001114099
NM_001114100
NM_012410
NM_201575
SEZ6L2



seizure related 6 homolog (mouse)-like 2



chr6_-_33028790 0.311 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr22_-_34886727 0.310 NM_145640
APOL3
apolipoprotein L, 3
chr2_-_233586164 0.304 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr2_+_68445821 0.304 NM_002664
PLEK
pleckstrin
chr17_+_6599879 0.304 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr17_-_16816113 0.303 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr2_-_233586145 0.303 NGEF
neuronal guanine nucleotide exchange factor
chr13_+_107720561 0.300 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr21_-_33107813 0.290 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr17_-_9864048 0.290 GAS7
growth arrest-specific 7
chr7_+_155129943 0.289 NM_053043
RBM33
RNA binding motif protein 33
chr19_+_40224480 0.287 HPN
hepsin
chrX_+_128741578 0.286 SASH3
SAM and SH3 domain containing 3
chr1_-_181889070 0.285 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr11_+_5367182 0.283 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr12_+_63510481 0.278


chr22_+_34979118 0.263 APOL1
apolipoprotein L, 1
chrX_-_46503540 0.261 SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr13_+_107720206 0.253 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr3_+_123779122 0.252 NM_001113523
PARP15
poly (ADP-ribose) polymerase family, member 15
chr10_+_80743769 0.248 ZMIZ1
zinc finger, MIZ-type containing 1
chrX_-_111809929 0.247 NM_178175
LHFPL1
lipoma HMGIC fusion partner-like 1
chr6_-_30188845 0.246 NM_007028
TRIM31
tripartite motif containing 31
chr14_-_93512818 0.244 ASB2
ankyrin repeat and SOCS box containing 2
chr13_+_107720475 0.243 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr11_+_66979393 0.241 NM_145200
CABP4
calcium binding protein 4
chr1_+_205328834 0.238 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr6_-_41811323 0.233 TFEB
transcription factor EB
chr16_+_4546491 0.228 NM_001145011
LOC342346
hypothetical protein LOC342346
chr1_-_149004852 0.226 CTSS
cathepsin S
chr4_-_116254381 0.225 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr17_+_53769562 0.223 LOC100506779
hypothetical LOC100506779
chr11_+_5610060 0.223 NM_130390
TRIM34
tripartite motif containing 34
chr22_+_38652555 0.222 GRAP2
GRB2-related adaptor protein 2
chr13_+_107719977 0.218 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr5_+_53787187 0.217 NM_006308
HSPB3
heat shock 27kDa protein 3
chr17_+_38256886 0.217


chr22_+_23309717 0.216 NM_013430
GGT1
gamma-glutamyltransferase 1
chr2_+_191009265 0.214 MFSD6
major facilitator superfamily domain containing 6
chr7_+_90176647 0.211 NM_012395
CDK14
cyclin-dependent kinase 14
chrX_+_46825179 0.209 RGN
regucalcin (senescence marker protein-30)
chr7_-_36992221 0.208 NM_130442
ELMO1
engulfment and cell motility 1
chr9_+_114376709 0.204 KIAA1958
KIAA1958
chr1_-_203657803 0.201 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr7_+_150013716 0.201 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr19_+_15699833 0.200 NM_013939
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr1_-_6343306 0.200 NM_181865
ACOT7
acyl-CoA thioesterase 7
chr1_-_111544603 0.198


chr2_-_96320185 0.194 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr6_+_52159143 0.191 NM_002190
IL17A
interleukin 17A
chr1_-_156800017 0.188 NM_001160325
OR6P1
olfactory receptor, family 6, subfamily P, member 1
chr22_-_41672990 0.185 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chrX_-_110400406 0.183 NM_014289
CAPN6
calpain 6
chr2_-_188086612 0.178 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr22_+_34979062 0.178 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr20_-_44612619 0.167 NM_080721
C20orf123
chromosome 20 open reading frame 123
chr1_+_50344550 0.167 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_+_94953148 0.167 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr1_-_9052207 0.163 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr17_+_44642587 0.162 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr16_-_29818334 0.161 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr22_+_22907443 0.160 NM_019601
SUSD2
sushi domain containing 2
chr12_+_12656022 0.159 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr12_-_46405477 0.159 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr7_+_155129904 0.156 RBM33
RNA binding motif protein 33
chr2_+_108360798 0.155 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr1_+_205329206 0.154 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr5_-_134810696 0.153 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr17_+_40594046 0.152 NM_144608
HEXIM2
hexamthylene bis-acetamide inducible 2
chr8_-_72436519 0.149 EYA1
eyes absent homolog 1 (Drosophila)
chr22_+_22907417 0.144 SUSD2
sushi domain containing 2
chr3_-_44527083 0.143 ZNF852
zinc finger protein 852
chr1_-_199613427 0.143 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr11_-_71424614 0.142


chr8_+_21967008 0.141 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr1_-_9052253 0.140 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr11_+_298106 0.140 NM_006435
IFITM2
interferon induced transmembrane protein 2 (1-8D)
chr1_-_24179326 0.137 SRSF10
serine/arginine-rich splicing factor 10
chr11_-_58368555 0.134 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr6_-_32268267 0.133 GPSM3
G-protein signaling modulator 3
chr12_+_61240542 0.132 MON2
MON2 homolog (S. cerevisiae)
chr19_-_14853166 0.131 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr5_-_169657395 0.130 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_+_38256710 0.128 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr10_-_49792282 0.126 NM_001006939
LRRC18
leucine rich repeat containing 18
chr10_+_7785331 0.125 ITIH2
inter-alpha (globulin) inhibitor H2
chr15_+_89248423 0.123 NM_006122
MAN2A2
mannosidase, alpha, class 2A, member 2
chr8_+_75066117 0.122 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr14_-_93829309 0.122 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr3_-_44527122 0.119 ZNF852
zinc finger protein 852
chr5_-_135318420 0.118 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr10_+_7785347 0.118 ITIH2
inter-alpha (globulin) inhibitor H2
chr11_-_16454493 0.117 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chrX_-_19727775 0.117 SH3KBP1
SH3-domain kinase binding protein 1
chr7_-_92693716 0.116 NM_001039372
HEPACAM2
HEPACAM family member 2
chr9_-_35818728 0.116 NM_001012446
C9orf128
chromosome 9 open reading frame 128
chr7_+_155130086 0.114 RBM33
RNA binding motif protein 33
chr12_-_121753795 0.114 NM_177551
GPR109A
G protein-coupled receptor 109A
chr1_+_100099353 0.114 NM_000645
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr1_-_246789396 0.113 NM_001004694
OR2T29
OR2T5
olfactory receptor, family 2, subfamily T, member 29
olfactory receptor, family 2, subfamily T, member 5
chr7_+_31693155 0.113 NM_001145123
NM_006658
C7orf16

chromosome 7 open reading frame 16

chr11_-_66431910 0.109 NM_022172
PC
pyruvate carboxylase
chr1_+_246703249 0.108 NM_001005495
OR2T3
olfactory receptor, family 2, subfamily T, member 3
chr3_+_52788976 0.107 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr14_-_93919305 0.104 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr18_+_41659542 0.104 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr1_-_199613406 0.103 TNNT2
troponin T type 2 (cardiac)
chr7_+_113853790 0.103 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr12_+_122510338 0.101 NM_180699
SNRNP35
small nuclear ribonucleoprotein 35kDa (U11/U12)
chr1_+_179164195 0.099


chr10_+_5228756 0.097 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr20_-_42457717 0.094


chr9_-_35860316 0.091 NM_001004487
OR13J1
olfactory receptor, family 13, subfamily J, member 1
chr16_-_70168449 0.090 NM_000353
TAT
tyrosine aminotransferase
chr2_-_166638376 0.090 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr10_+_7785235 0.089 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr10_-_121286034 0.089 NM_002925
RGS10
regulator of G-protein signaling 10
chr6_+_43005126 0.089 CNPY3
canopy 3 homolog (zebrafish)
chr9_-_91284430 0.088 NM_001142287
NM_006378
SEMA4D

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

chr1_-_149004879 0.086 CTSS
cathepsin S
chr5_+_155686750 0.084 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr18_-_28606839 0.084 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr12_+_12656109 0.084 CREBL2
cAMP responsive element binding protein-like 2
chrX_+_102918453 0.084 PLP1
proteolipid protein 1
chr5_+_169749068 0.083


chr6_+_44302973 0.083 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr12_+_27511009 0.082 NM_001145010
C12orf70
chromosome 12 open reading frame 70
chr14_-_20179689 0.081 NM_001001968
OR6S1
olfactory receptor, family 6, subfamily S, member 1
chr12_+_27740694 0.081 NM_001029874
REP15
RAB15 effector protein
chr20_-_57940567 0.081 NM_014258
SYCP2
synaptonemal complex protein 2
chr22_-_38258716 0.081 NM_194326
RPS19BP1
ribosomal protein S19 binding protein 1
chr5_+_139856688 0.080 ANKHD1
ankyrin repeat and KH domain containing 1
chr19_+_42553895 0.079 NM_032453
ZNF527
zinc finger protein 527
chrX_+_102918409 0.079 NM_000533
NM_199478
PLP1

proteolipid protein 1

chrX_+_85404626 0.078 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr2_-_25320299 0.078 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_+_6537924 0.077 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr12_+_56114724 0.077 NM_005538
INHBC
inhibin, beta C
chr11_-_116168316 0.076 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr22_+_20880112 0.076


chr19_-_38052481 0.075 NM_001126335
NM_014270
SLC7A9

solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

chr3_+_120982020 0.075 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr9_+_35663852 0.074 NM_001216
CA9
carbonic anhydrase IX
chr15_+_38886546 0.074 NM_001077268
ZFYVE19
zinc finger, FYVE domain containing 19
chr4_+_88961573 0.072 NM_001184694
MEPE
matrix extracellular phosphoglycoprotein
chrX_-_110400321 0.072 CAPN6
calpain 6
chr7_+_72883128 0.070 NM_001305
CLDN4
claudin 4
chr1_-_169888373 0.067 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr4_+_39084936 0.066 KLB
klotho beta
chr20_+_45564007 0.066 NM_001174087
NM_001174088
NM_006534
NM_181659
NCOA3



nuclear receptor coactivator 3



chr11_+_72658586 0.065 NM_176798
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.32 1.52e-12 GO:0007606 sensory perception of chemical stimulus
4.48 5.00e-12 GO:0007608 sensory perception of smell
3.02 2.01e-09 GO:0007600 sensory perception
2.28 6.50e-07 GO:0050877 neurological system process
2.00 2.06e-05 GO:0003008 system process
1.38 3.33e-04 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.39 7.67e-03 GO:0071944 cell periphery
1.30 2.59e-02 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.70 2.37e-13 GO:0004984 olfactory receptor activity
2.97 5.17e-10 GO:0004930 G-protein coupled receptor activity
2.38 2.98e-08 GO:0004888 transmembrane receptor activity
2.07 4.10e-07 GO:0004872 receptor activity
1.81 3.78e-05 GO:0004871 signal transducer activity
1.81 3.78e-05 GO:0060089 molecular transducer activity